标签归档：smcc

SMCC/Maleimidocyclohexane NHS Cat. No. SMC01 MW 334.33 25 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC/Maleimidocyclohexane NHS

Cat. No. SMC01 SMCC/Maleimidocyclohexane NHS Cat. No. SMC01 MW 334.33 25 mg
Specification MW 334.33
Unit Size 25 mg
Price $385.00

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Name: Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate, SMCC

Synonym: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

Description about SMCC:

SMCC, also called Succinimidyl cyclohexane Maleimide, is one of  Nanocs' amine and sulfhydryl reactive crosslinkers. This crossliner is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties of SMCC:

  • Appearance: Off-white/white solid;
  • Molecular formula: C16H18N2O6;
  • Molecular weight: 334.32;
  • Spacer arm length: 8.3 angstrom, 9 atoms
  • CAS number: 64987-85-5;
  • Purity: >95%
  • Soluble in DMF or DMSO;

Storage Conditions of SMCC:

  • SMCC should be stored at -20 0C or lower. Desiccate. Avoid frequent thaw and freeze.

SMCC-PEG4-NHS Cat. No. M2-P4S-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG4-NHS

Cat. No. M2-P4S-1 SMCC-PEG4-NHS Cat. No. M2-P4S-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

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Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) is an amine and sulfhydryl reactive crosslinker. This crosslinker is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the maleimide NHS a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/brownish solid or semi-solid;
  • Reactivity: Reactive to sulfhydryl and amine groups;
  • Solubility: Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG12-NHS Cat. No. M2-P12S-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG12-NHS

Cat. No. M2-P12S-1 SMCC-PEG12-NHS Cat. No. M2-P12S-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

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Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) is an amine and sulfhydryl reactive crosslinker. This crosslinker is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the maleimide NHS a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/brownish solid or semi-solid;
  • Reactivity: Reactive to sulfhydryl and amine groups;
  • Solubility: Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG23-NHS Cat. No. M2-P23S-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG23-NHS

Cat. No. M2-P23S-1 SMCC-PEG23-NHS Cat. No. M2-P23S-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) is an amine and sulfhydryl reactive crosslinker. This crosslinker is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the maleimide NHS a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/brownish solid or semi-solid;
  • Reactivity: Reactive to sulfhydryl and amine groups;
  • Solubility: Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG45-NHS Cat. No. M2-P45S-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG45-NHS

Cat. No. M2-P45S-1 SMCC-PEG45-NHS Cat. No. M2-P45S-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) is an amine and sulfhydryl reactive crosslinker. This crosslinker is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the maleimide NHS a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/brownish solid or semi-solid;
  • Reactivity: Reactive to sulfhydryl and amine groups;
  • Solubility: Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccated. Avoid frequent thaw and freeze.

SMCC-PEG4-NH2 Cat. No. M2-P4A-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG4-NH2

Cat. No. M2-P4A-1 SMCC-PEG4-NH2 Cat. No. M2-P4A-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) amine is a heterobifunctional crosslinker that can react with sulfhydryl and amine reactive groups, such as NHS ester. This crosslinker contains a sulfhydryl reactive maleimide group and a primary amine group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the cyclohexane maleimide PEG amine a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. Maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/white solid or semi-solid;
  • Reactivity: Reactive to thiols and activitated carboxylic groups.
  • Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccate. Avoid frequent thaw and freeze.

SMCC-PEG12-NH2 Cat. No. M2-P12A-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG12-NH2

Cat. No. M2-P12A-1 SMCC-PEG12-NH2 Cat. No. M2-P12A-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) amine is a heterobifunctional crosslinker that can react with sulfhydryl and amine reactive groups, such as NHS ester. This crosslinker contains a sulfhydryl reactive maleimide group and a primary amine group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the cyclohexane maleimide PEG amine a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. Maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/white solid or semi-solid;
  • Reactivity: Reactive to thiols and activitated carboxylic groups.
  • Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccate. Avoid frequent thaw and freeze.

SMCC-PEG23-NH2 Cat. No. M2-P23A-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG23-NH2

Cat. No. M2-P23A-1 SMCC-PEG23-NH2 Cat. No. M2-P23A-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) amine is a heterobifunctional crosslinker that can react with sulfhydryl and amine reactive groups, such as NHS ester. This crosslinker contains a sulfhydryl reactive maleimide group and a primary amine group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the cyclohexane maleimide PEG amine a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. Maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/white solid or semi-solid;
  • Reactivity: Reactive to thiols and activitated carboxylic groups.
  • Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccate. Avoid frequent thaw and freeze.

SMCC-PEG45-NH2 Cat. No. M2-P45A-1 5 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

SMCC-PEG45-NH2

Cat. No. M2-P45A-1 SMCC-PEG45-NH2 Cat. No. M2-P45A-1 5 mg
Specification
Unit Size 5 mg
Price $385.00

Qty Add to Cart

Description:

Nanocs SnapLinkTM pegylated succinimidyl cyclohexane Maleimide (SMCC) amine is a heterobifunctional crosslinker that can react with sulfhydryl and amine reactive groups, such as NHS ester. This crosslinker contains a sulfhydryl reactive maleimide group and a primary amine group bridged with PEG arm. The hydrophilic polyethylene glycol (PEG) spacer arm imparts water solubility that is transferred to the crosslinked molecules , thus reducing aggregation of labeled proteins in solution. The PEG spacer arm also gives the cyclohexane maleimide PEG amine a long and flexible structure to minimize steric hindrance for its reaction to other molecues. Compared to other maleimide NHS ester, SMCC has higher stability in aqueous solution because of its cyclohexane bridge. Maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties:

  • Appearance: Off-white/white solid or semi-solid;
  • Reactivity: Reactive to thiols and activitated carboxylic groups.
  • Soluble in DMF or DMSO;

Storage Conditions:

  • Store at -20 0C, desiccate. Avoid frequent thaw and freeze.

LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate)) Cat. No. SMCC-LC-1 MW 444.78 100 mg修饰性聚乙二醇

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上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

LC-SMCC (succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate))

Cat. No. SMCC-LC-1
Specification MW 444.78
Unit Size 100 mg
Price $485.00

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Name: LC-SMCC, Long chain-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

Synonym: LC-SMCC, long chain 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester

Description:

LC-SMCC, also called Long chain succinimidyl cyclohexane Maleimide, is one of  Nanocs' amine and sulfhydryl reactive crosslinkers. This crossliner is non-cleavable and membrane permeable. It contains an amine reactive NHS ester and a sulfhydryl reactive maleimide group. Compared to other maleimide NHS ester, LC-SMCC has higher stability in aqueous solution because of its cyclohexane bridge. NHS esters react with primary amines at pH 7-9 while the maleimide group reacts with available thiol or sulfhydryl at pH 6.5~7.5 to form stable thioether bonds.

Physical Properties of SMCC:

  • Appearance: Off-white/white solid;
  • Molecular formula: C22H29N3O7;
  • Molecular weight: 447.48;
  • Reactive to: Sulfhydryl and primary amine group;
  • Purity: >95%
  • Soluble in DMF or DMSO;

Storage Conditions of LC-SMCC:

  • LC-SMCC should be stored at -20 0C or lower. Desiccate. Avoid frequent thaw and freeze.

SMCC Crosslinker/cas64987-85-5/异型双功能交联剂/N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate

发表于由

SMCC Crosslinker/cas64987-85-5/异型双功能交联剂/N-Succinimidyl 4-(N-maleimidomethyl)cyclohexhaie-1-carboxylate  

SMCC Crosslinker cas64987-85-5 异型双功能交联剂

 金畔生物是一家生产蛋白质生物化学、有机物质合成的生物技术与化学试剂公司，产品适用于核磁共振，质谱，蛋白质交联剂和新的蛋白质检测蛋白质相关产品以及用于质谱，药物开发，诊断和蛋白质的生物化学试剂。例如：氘交联剂、固定化树脂、生物素化试剂、纯化酶等特色试剂、蛋白质改性试剂等等。

 产品说明：

英文名称：  N-Succinimidyl 4-(N-maleimidomethyl)cyclohexhaie-1-carboxylate  

中文名称：4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯  

MF：C16H18N2O6  

MW：334.32  

CAS：64987-85-5

SMCC Crosslinker/cas64987-85-5/异型双功能交联剂/N-Succinimidyl 4-(N-maleimidomethyl)cyclohexhaie-1-carboxylate 

SMCC交联剂（琥珀酰亚胺基-4-[N-马来酰亚胺甲基]环己烷-1-羧酸酯）是一种异双功能蛋白质交联剂。SMCC结合通过巯基（巯基；-SH）反应的马来酰亚胺基团和胺反应的NHS酯基团发生，形成稳定的共价蛋白质交联。SMCC交联剂必须溶解在有机溶剂中，如DMSO或DMF，然后可以添加到水性交联反应中。SMCC交联试剂可穿过细胞膜的脂质双层，并可用于交联细胞内蛋白质和肽。

SMCC是生产稳定的马来酰亚胺活化载体蛋白的首选试剂，可与巯基（硫醇）反应。SMCC的9-原子不可裂解间隔臂中的环己烷环降低了马来酰亚胺基团的水解速率。因此，可以将用SMCC活化的马来酰亚胺的蛋白质冻干、储存，然后与含巯基的分子结合。许多马来酰亚胺活化蛋白产品是通过这种方式生产的，首先通过SMCC交联试剂的NHS酯在载体蛋白上与赖氨酸残基中发现的伯胺形成交联，并将其转化为反应性马来酰亚胺。因此，马来酰亚胺活化的中间体非常稳定，可以冷冻干燥，并储存起来，以便以后与半抗原结合以产生抗体。

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厂家：上海金畔生物科技有限公司

用途：科研

状态：固体/粉末/溶液

产地：上海

储存时间：1年

保存：冷藏

储藏条件：-20℃

磺基SMCC交联剂|Sulfo-SMCC Crosslinker

发表于由
磺基SMCC交联剂|Sulfo-SMCC Crosslinker

磺基-SMCC钠盐/4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐/英文名称：SULFO-SMCC/Sulfo-SMCC Crosslinker 分子式：C16H17N2NaO9S 分子量：436.4

产品介绍

Sulfo-SMCC Crosslinker

英文名称：SULFO-SMCC    

                 Sulfo-SMCC Crosslinker

                 Sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate

中文名称：磺基-SMCC钠盐

                 4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐

分子式：C16H17N2NaO9S

分子量：436.4

CAS：92921-24-9

MDL：MFCD00054978

纯度：≥95%

性    状:白色或微黄色粉状制剂 

用    途：仅供科研实验使用，不用于诊治 

注意事项：取用一定要干燥，避免频繁的溶解和冻干 

溶解性：溶于大部分有机溶剂，如：DCM、DMF、DMSO、THF等等。在水中有很好的溶解性。

储存时间：1年

用途：科研

产地：上海

温馨提醒：仅供科研，不能用于人体实验

 

参数信息
外观状态： 固体或粉末
质量指标： 95%+
溶解条件： 有机溶剂/水
CAS号： N/A
分子量： N/A
储存条件： -20℃避光保存
储存时间： 1年
运输条件： 室温2周
生产厂家： 上海金畔生物科技有限公司