上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
DODAP (1,2-dioleoyl-3-dimethylammonium-propane)
|
Description:
DODAP (1,2-dioleoyl-3-dimethylammonium-propane) is an ionizable cationic lipid with low cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). The electrostatic interactions between DODAP and naturally occurring anionic lipids in endosomal membranes trigger the release of nucleic acid. These interactions promote membrane lytic non-bilayer structures to enable the intracellular delivery of nucleic acid. A common application is in nanomedicine as an ionizable lipid component of nanocarriers (lipid-polymer hybrid nanoparticles, LPNs), widely used to encapsulate bioactive molecules, including mRNA, siRNA, and plasmid DNA as a treatment for diseases.
Specifications:
- Form: Liquid;
- Color: Light yellow liquid;
- Formular: C41H77NO4;
- Molecular weight: 648.05;
- Lipid type: C18, un-saturated ionizable lipids;
Applications:
- DNA, SiRNA, mRNA transfection;
- Drug delivery;
- Gene therapy;
Storage:
- Store at -20 0C. Protect from light.
Click to enlarge
| DOTAP-MS , DOTAP Methyl Sulfate |