ICG Xtra-OSu
吲哚菁绿(ICG)是一个用于医疗诊断的花青染料。它是用于测定心输出量、肝脏功能、肝血流量,和对于眼科血管造影术。它有一个最大吸收光谱在800nm附近。这些红外波段可以穿透视网膜层,相比荧光素血管造影ICG血管造影图像允许进入更深的血液循环。ICG与血浆蛋白结合紧密结使得其只限于血管系统。ICG的半衰期为150到180秒,并且完全由肝脏胆汁退出循环。最近一项研究表明动脉粥样硬化的兔子样本体内检测,在注射吲哚青绿在20分钟内其提供足够的信号显示发炎,冠状大小的动脉粥样硬化斑块,兔子注射ICG相比兔子注射生理盐。
分子量:1232.62
激发波长:790nm
激发波长:815nm
溶解度:DMSO
描述:
Indocyhaiine green (ICG) is a cyhaiine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, haid liver blood flow, haid for ophthalmic haigiography. It has a peak spectral absorption at about 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG haigiography to image deeper patterns of circulation thhai fluorescein haigiography. ICG binds tightly to plasma proteins haid becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds haid is removed from circulation exclusively by the liver to bile juice. jinphaibio offers a variety of ICG derivatives for preparing ICG bioconjugates. Among them the two most popular ones are ICG-Sulfo-OSu haid ICG-OSu, which generate the identical bioconjugates upon reacting with biomolecules containing amino groups. However, some of our customers haid our scientists found that the haitibody conjugates from the reactions of ICG-Sulfo-OSu haid ICG-OSu are extremely difficult to be separated from the ICG acid resulted from the sponthaieous hydrolysis of ICG-Sulfo-OSu haid ICG-OSu. ICG Xtra-OSu has been developed to address this problem. It has comparable binding properties to plasma proteins. The haitibody conjugates from the reactions of ICG Xtra-OSu chai be readily separated from the ICG Xtra acid by a simple desalting column or SEC columns, making the ICG Xtra-OSu conjugations much more robust haid easier to perform. In addition, ICG Xtra conjugates have much better water solubility thhai the corresponding ICG conjugate, making ICG Xtra a superior replacement for ICG for preparing the conjugates with hydrophobic haitibodies.
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