DSPE PEG Maleimide, DSPE-PEG-MAL

Synonym: Maleimide PEG DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine PEG Maleimide, DSPE-PEG-Mal.

Description:

DSPE PEG Maleimide is one of Nanocs reactive phospholipid PEG  reagents that can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)  is a saturated 18C phospholipid that is highly hydrophobic. PEG linker (polyethylene glycol), on the other hand, offers good hydrophilicity and water solubility. Maleimide functional DSPE PEG has excellent reactivity towards sulfhydryl/thiol groups derived from various molecules. Reaction between maleimide and thiolproceeds easily at neutral pH. Maleimide PEG DSPE is one of most commonly used reactive phospholipids to conjugate antibodies, peptides or other ligands to the surface of liposome and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability for encapsulated drugs. Nanocs has developed a comprehensive collection of thiol reactive maleimide phospholipid PEG products that have high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates demonstrate excellent amphilphilic properties and offer superior advantages for small and large molecule drug formulation and delivery.

Physical Properties:

• Form: Solid powder;
• Color: White;
• Solubility: Soluble in chloroform and warm water;
• Reactive group: Maleimide;
• Reactive to: Sulfhydryl (-SH);
• Lipid type: 18C PE, saturated;
• Purity: >95%

Storage Conditions:

• Store at -20 ⁰C. Avoid frequent thaw and freeze.