ADC(抗体药物偶联物)的组成条件及基本原理
ADC由以下三部分组成：
1 抗体（haitibody）：其作用是特异性识别靶细胞
2 毒素（drug）：起到*伤细胞的作用
2 连接物（linker）：连接抗体与毒素
其实简单来看，ADC就是单克隆抗体与化疗的一种组合疗法，既具有单抗的选择性，又具有化疗的*伤力。在患者接受ADC治疗之后，ADC将会进入患者的体内循环，一旦ADC的抗体部分特异性地结合到肿瘤细胞表面，肿瘤细胞的细胞膜将会向内凹陷，形成内体囊泡（endosome）将ADC吞入，这个过程又称为内化（internaliztion）；ADC的抗体部分或linker在细胞内往往会被一些酶类降解，从而将毒素释放出来，释放出的毒素便开始发挥作用，*伤细胞（不同的毒素*伤细胞原理不同，但大多数毒素是在细胞核内发挥功能）。如下图所示：
上海金畔生物供应ADC(抗体药物偶联物)相关产品目录：
| 产品cas |
产品名称 |
| 2055024-64-9 |
Azido-PEG4-Val-Cit-PAB-OH |
| 2280998-74-3 |
m-PEG11-acid |
| 2353409-80-8 |
Gly-Gly-Gly-PEG4-DBCO |
| 1392499-32-9 |
N-Boc-PEG5-bromide |
| 1144113-16-5 |
Tr-PEG8-OH |
| 2353409-81-9 |
Gly-Gly-Gly-PEG3-TCO |
| 1347750-80-4 |
Propargyl-PEG4-thiol |
| 54384-47-3 |
NH-bis-PEG2 |
| 42607-87-4 |
THP-PEG6-OH |
| 2028281-86-7 |
Mal-Sulfo-DBCO |
| 68528-80-3 |
DSS Crosslinker |
| 756526-02-0 |
Fmoc-NH-PEG8-CH2CH2COOH |
| 2055014-97-4 |
Bis-(PEG6-acid)-SS |
| 2112738-13-1 |
Mal-amido-PEG2-Val-Cit-PAB-PNP |
| 2112738-09-5 |
Mal-PEG4-Val-Cit-PAB-PNP |
| 866363-70-4 |
N3-C5-NHS ester |
| 39160-70-8 |
Amino-PEG6-alcohol |
| 477775-57-8 |
m-PEG7-Ms |
| 236426-37-2 |
Fmoc-Gly-Gly-Phe-OtBu |
| 2144395-59-3 |
DBCO-PEG5-NHS ester |
| 65869-64-9 |
Bis-PEG1-NHS ester |
| 2100306-58-7 |
DBCO-NHCO-PEG4-NHS ester |
| 85916-13-8 |
NH-bis(C1-Boc) |
| 110429-45-3 |
m-PEG4-Br |
| 2055024-65-0 |
Azido-PEG3-Val-Cit-PAB-OH |
| 1491152-23-8 |
Mal-L-PA-NH-Boc |
| 2101206-46-4 |
NHPI-PEG4-C2-Pfp ester |
| 2093154-01-7 |
N-Boc-N-bis(PEG4-OH) |
| 2055048-54-7 |
Azido-PEG5-Ala-Ala-Asn-PAB |
| 1214319-92-2 |
Azido-PEG8-acid |
| 94376-75-7 |
Bis-PEG7-acid |
| 180608-78-0 |
N-(5-Hydroxypentyl)maleimide |
| 1807518-77-9 |
Fmoc-N-methyl-PEG3-CH2CH2COOH |
| 872679-70-4 |
Fmoc-NH-PEG2-CH2CH2COOH |
| 180608-78-0 |
N-(5-Hydroxypentyl)maleimide |
| 2101206-30-6 |
Propargyl-O-C1-amido-PEG2-C2-NHS ester |
| 1393330-40-9 |
Propargyl-PEG5-NHS ester |
| 943858-70-6 |
N3-C3-NHS ester |
| 1292268-13-3 |
N-Boc-PEG7-alcohol |
| 1374666-32-6 |
Mal-PEG2-acid |
| 217180-81-9 |
Azido-PEG5-CH2CO2H |
| 784105-33-5 |
Amino-PEG3-C2-acid |
| 1234369-95-9 |
m-PEG7-CH2CH2CHO |
| 1306615-51-9 |
Aminooxy-PEG3-azide |
| 184357-46-8 |
m-PEG6-Amine |
| 170908-81-3 |
DOTA-NHS-ester |
| 1333154-77-0 |
Azido-PEG7-amine |
| 2228857-32-5 |
Azidoethyl-SS-propionic acid |
| 883554-11-8 |
m-PEG4-Boc |
| 1807521-07-8 |
Ald-Ph-amido-PEG2-C2-NHS ester |
| 2055048-57-0 |
Fmoc-PEG4-Ala-Ala-Asn-PAB |
| 2353409-69-3 |
Mal-PEG8-Val-Cit-PAB-MMAE |
| 1383658-09-0 |
m-PEG10-amine |
| 130955-37-2 |
m-PEG4-Ms |
| 756525-91-4 |
Boc-NH-PEG4-CH2CH2COOH |
| 1325208-25-0 |
Mal-PEG4-NHS ester |
| 169751-10-4 |
Sulfo-SPDP-C6-NHS sodium |
| 74654-07-2 |
m-PEG3-Amine |
| 253863-34-2 |
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP |
| 229977-57-5 |
MAC glucuronide linker-2 |
| 791028-27-8 |
Amino-PEG2-C2-acid |
| 55750-61-3 |
AMAS |
| 1263044-56-9 |
MC-PEG2-C2-NHS ester |
| 185022-12-2 |
Aminooxy-PEG2-alcohol |
| 882847-34-9 |
Fmoc-NH-PEG6-CH2CH2COOH |
| 1061569-06-9 |
Ald-Ph-amido-PEG2 |
| 132178-37-1 |
Propargyl-C1-NHS ester |
| 1807503-88-3 |
THP-SS-PEG1-Boc |
| 875770-32-4 |
Propargyl-PEG4-Tos |
| 2055014-98-5 |
Acid-PEG3-SS-PEG3-acid |
| 2182601-68-7 |
DBCO-PEG4-DBCO |
| 2110448-97-8 |
Gly-PEG3-amine |
| 1599440-15-9 |
MC-Gly-Gly-Phe |
| 1599472-25-9 |
Mal-PEG6-NHS ester |
| 331242-61-6 |
N-Boc-PEG6-alcohol |
| 1008402-79-6 |
Bis-PEG9-NHS ester |
| 876345-13-0 |
Boc-NH-PEG4-CH2COOH |
| 1002342-83-7 |
Ald-CH2-PEG3-azide |
| 1884578-00-0 |
Boc-Val-Ala-PAB-PNP |
| 1286837-77-1 |
trhais-Sulfo-SMCC |
| 1309460-27-2 |
Ald-Ph-amido-PEG4-C2-acid |
| 2101206-86-2 |
SPDMV-sulfo |
| 1391914-41-2 |
Propargyl-PEG1-SS-alcohol |
| 1395786-30-7 |
DBCO-Maleimide |
| 67319-28-2 |
m-PEG3-CH2CH2COOH |
| 27425-92-9 |
m-PEG10-alcohol |
| 1257063-35-6 |
Azido-PEG4-C2-acid |
| 2101206-21-5 |
Ald-Ph-amido-PEG3-C2-Pfp ester |
| 1415328-95-8 |
NHPI-PEG4-C2-NHS ester |
| 1347760-82-0 |
Propargyl-PEG3-acid |
| 1353012-00-6 |
N3-PEG4-C2-Pfp ester |
| 1807518-67-7 |
Bromoacetamido-PEG4-acid |
| 635287-26-2 |
Fmoc-NH-PEG5-CH2COOH |
| 955094-26-5 |
Mal-amido-PEG2-NHS ester |
| 881895-59-6 |
6-O-2-Propyn-1-yl-D-galactose |
| 178685-33-1 |
Azide-PEG3-Tos |
| 1043426-13-6 |
Aminooxy-PEG2-azide |
| 2055041-39-7 |
Mal-PEG4-Val-Cit-PAB-OH |
| 1007215-94-2 |
Ald-Ph-amido-PEG3-C1-Boc |
| 1116086-09-9 |
Fmoc-Phe-Lys(Trt)-PAB-PNP |
| 478801-48-8 |
N3-C4-NHS ester |
