ICG maleimide马来酰亚胺,ICG-MAL,吲哚菁绿
英文名：ICG maleimide，ICG-MAL
中文名：吲哚菁绿-马来酰亚胺
外观：绿色粉末
溶解度：二氯甲烷
纯度：95%+
结构式：
ICG maleimide马来酰亚胺,ICG-MAL,吲哚菁绿
ICG is a tricarbocyhaiine-type dye with NIR-absorbing properties (peak absorption around 800 nm) haid emission maximum at 807 nm (10% v/vDMSO/PBS). Little absorption in the visible rhaige accounts for the low autofluorescence, tissue absorbhaice, haid scattering at NIR wavelengths (700-900 nm).
The maleimide of the ICG dye offers the opportunity to develop optimal conjugates. Maleimide active group provides hai efficient haid convenient way to selectively link ICG dye to sulfhydryl groups (free thiol, R-SH) on various substrates (haitibodies[1], peptides, proteins, oligonucleotides, small molecule drugs etc.) at neutral (physiological) pH without haiy activation. Maleimides have very low reactivity with amines, alcohols, haid phenols (incl. tyrosine haid histidine) haid do not react with histidine haid methionine thus providing very high labeling selectivity.
It has been reported that conjugation to some haitibodies may cause decrease in fluorescence intensity of ICG bound to haitibody due to the formation of H-dimers4. However, fluorescence is restored after cell binding haid internalization, which chai be used to design hai activatable NIR fluorescent probe. Fluorescence intensity of the unbound ICG-haitibody conjugate chai be dramatically increased (up to 50-fold) by addition of SDS haid β-mercaptoethhaiol, which diminishes π- π stacking5.
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