美国戴安Dionex Acclaim Trinity P1 Series 液相色谱柱
简要描述:
戴安公司生产的仪器主要有离子色谱仪、高效液相色谱仪、快速溶剂萃取仪和氨基酸直接分析仪。其中离子色谱仪凭借着雄厚的技术优势和方法已广泛地应用于各个领域,其市场占有率达80%。与离子色谱相关的文章有90%均出自戴安公司生产的离子色谱仪。 戴安公司的快速溶剂萃取仪15分钟之内仅用15毫升溶剂既可完成对10g样品的萃取,该技术已在环境、药物、食品和聚合物工业等领域得到广泛应用。
型号 | 075563 |
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Acclaim Trinity P1 Series
Acclaim Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances and their counterions. This new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily optimized by adjusting phase buffer concentration, pH, and solvent content concurrently or independently. The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.
NSH Chromatographic Features
- Multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange
- Adjustable selectivity by phase ionic strength, electrolyte type, pH, and organic solvent
- Ideal selectivity for simultaneous separation of basic, neutral, and acidic analytes
- Separation of hydrophilic ionic and ionizable analytes without ion-pairing reagents
Acclaim Trinity P1 Applications
- Active pharmaceutical ingredients (API) and counterions (cations or anions)
- Screening of pharmaceutical counterions. Both UV and evaporative light scattering (ELS) detectors, in series, are required for simultaneous determination of both drug substances and counterions.
- Mixture of acidic and basic drug substances and respective counterions
- Drug substances of acidic, basic, and neutral mixtures
- High throughput analysis following optimization of the selectivity and resolution. The flow rate can then be increased, and the analysis time shortened.
技术参数:
Acclaim Trinity P1 Column – Superior Performance for Pharmaceutical Applications Specifications | |
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Column chemistry | SCX, WAX and RP Mixed-Mode |
Operating pressure limit (recommended) | 4500 psi (4000 psi) |
Operating pH range (recommended) | 2.5 – 7.0 (3.0 to 6.2) |
Operating flow rate range (recommended) | 0.3 – 1.5(0.4 – 0.8) mL/min for 3.0-mm i.d. formats 0.15 – 0.80 (0.2 to 0.4) mL/min for 2.1-mm i.d. formats |
订购信息:
Analytical Columns | |
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Acclaim Trinity P1, 3µm, 3.0 x 150mm | 075563 |
Acclaim Trinity P1, 3µm Analytical, (3.0 x 100mm) | 071387 |
Acclaim Trinity P1, 3µm Analytical, (3.0 x 50mm) | 071388 |
Acclaim Trinity P1, 3µm, 2.1 x 150mm | 075564 |
Acclaim Trinity P1, 3µm Analytical, (2.1 x 100mm) | 071389 |
Acclaim Trinity P1, 3µm, 2.1 x 50mm | 075565 |
Guard Columns | |
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Acclaim Trinity P1, 3µm Guard Cartridges, (3.0 x 10mm), 2ea (Use Holder V-2) | 071390 |
Acclaim Trinity P1, 3µm Guard Cartridges, (2.1 x 10mm), 2ea (Use Holder V-2) | 071391 |
Acclaim SST Guard Cartridge Holder V-2 | 069580 |
Acclaim Guard Kit (Holder and coupler) V-2 | 069707 |
Guard to Analytical Column Coupler V-2 | 074188 |